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Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein
《环境科学与工程前沿（英文）》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1615-2
● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42.
关键词： Polycyclic aromatic hydrocarbons Nicotine toxicology Aβ42 peptide Alzheimer’s disease Molecular dynamics simulations Environmental pollution
Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,
《医学前沿（英文）》 2009年 第3卷 第3期 页码 330-335 doi: 10.1007/s11684-009-0051-4
关键词： Parkinson disease nicotine dopaminergic neuron gamma-aminobutyric acid neuron
Nicotine gum or patch treatment for smoking cessation and smoking reduction: a multi-centre study in
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《医学前沿（英文）》 2014年 第8卷 第1期 页码 84-90 doi: 10.1007/s11684-014-0311-9
In China, around 23% of physicians (41% male, 3% female) currently smoke. Pharmacotherapy for tobacco dependence is available, but is not widely used in China. The purpose of this study was to estimate the effectiveness and the safety on smoking cessation of nicotine gum and nicotine patch in Chinese healthcare professionals. Three hundred regular smokers motivated to quit were recruited from six hospitals in China. All subjects were accepted nicotine replacement therapy, and they could choose nicotine gum (2 mg or 4 mg, depending on baseline smoking level) or nicotine patch (15 mg/16 h) for 12 weeks, with a 12-week follow-up. Limited behavioural support was provided. At Week 24, the 2--24 weeks continuous abstinence rate (verified by expired carbon monoxide) was 17%, the point prevalence abstinence rate (no smoking since the previous visit) was 35%, and 38% of subjects had continuously reduced their daily cigarette consumption by at least 50% versus baseline. Compliance with treatment was good, particularly with patch. No serious adverse event was reported, and most adverse events were mild or moderate. The most common treatment-related adverse events were gastro-intestinal (both gum and patch) and local irritation symptoms. Nicotine patch and gum were well tolerated in Chinese smokers. Abstinence rates were comparable to those previously reported with nicotine replacement therapy, and many smokers who did not quit substantially reduced their cigarette consumption.
关键词： nicotine replacement therapy smoking cessation Chinese physicians
标题 作者 时间 类型 操作
Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with
Lei FU MD , Dezheng GONG BM , Yan PENG , Dongmei WANG BM , Hong XU , Yue LI MD , Dengqin YU BS , Yanhui FENG MD , Shengming YIN PhD , Jin GONG , Yiping SUN PhD ,
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